Top 8 DeSci Projects in 2025

OriginTrail is among the top DeSci projects. It is an Ethereum coin that bills itself as a “decentralized knowledge graph.” OriginTrail is used to find, handle, and store data for various applications, such as supply chain tracing and certificate, art, and diploma verification. The TRAC token covers the network’s data processing and storage costs. Anyone may participate in trustworthy information sharing with OriginTrail Decentralized information Graph, which combines blockchain and knowledge graph technology to enable a universe of AI-ready Knowledge Assets. Through the NeuroWeb, the DKG innovation center on Polkadot, OriginTrail is increasing adoption. OriginTrail is designed for network effects across many blockchain ecosystems.

The DKG operates using the Trace token (TRAC), which is intended to reward appropriate protocol behavior. It is a utility token that powers the whole DKG and must carry out tasks like publishing on the network. On the Ethereum network, TRAC was introduced 2018 as an ERC-20 token with a 500,000,000 token production limit.

Hippocrat (HPO) is the new brand for Humanscape (HUM) and has the second position among the top DeSci projects. Hippocrat is a blockchain-based decentralized patient network. Hippocrats can assist patients in overcoming their illnesses by fostering intellectual and emotional exchanges through community-based activities. The market capitalization of Hippocrat (HPO) is $99,405,809, and as of November 18, 2021, the highest price paid for Hippocrat (HPO) was $0.9947. 

Hippocrat offers a protocol that permits data to be exchanged and used by the self-determination of the data subject. If financial gain is realized during this process, compensation is also given to all parties involved in the data’s creation and processing, including the data subject. Furthermore, there will be no chance of forgery or tampering because the entire distribution process—from data creation to data utilization—will be transparent and recorded on the blockchain, allowing us to fully collaborate without depending on the confidence of outside parties.

VitaDAO’s primary goal is to support research on longevity by creating and promoting longevity-related intellectual property. A community-owned organization called VitaDAO finances and supports research on longevity that can lengthen people’s lives via smart contracts on the Ethereum network, VitaDAO functions. Members who own VITA can freely participate in governance decisions related to the cash and assets owned by VitaDAO, thanks to VitaDAO’s smart contract architecture. The native ERC20 token 64,298,880 VITA was created and is managed by VitaDAO. Members can indicate their long-term support for specific initiatives by using VITA tokens. Until a project milestone is met, members may stake their VITA DeSci projects for a predetermined time (3 months/6 months/12 months).

Anyone may earn ResearchCoin, a reward currency, by participating in ResearchHub discussions and sharing and curating academic science. The amount of RSC that may be obtained for a particular activity is determined by how useful the community thinks it is. By adding DeSci projects to ResearchHub, you may earn ResearchCoin (RSC) digital token. RSC is used on ResearchHub to appropriately acknowledge and commend people who contribute to the community’s value creation and, in doing so, foster unity among the scientific community.

There is now a $1 billion supply of RCS coins; however, in the future, the research hub community has the power to vote to change or increase the number of RSCs allotted to any of these entities. By sharing, selecting, and debating subjects on the site, ResearchHub users may accrue and exchange tokens with one another. On the site, users can also trade tokens with one another by making “bounties” that encourage other users to interact with their posts.

Dynex (DNX) is a peer-to-peer, open-source cryptocurrency that is part of the DePIN (Decentralised Physical Infrastructure) story. It is regarded as an altcoin and was introduced in September 2022 to use a Proof-of-Useful-Work (PoUW) mining algorithm to reimagine the cryptographic challenge and increase the significance of mining. Everyone may access supercomputing capacity by utilizing the combined power of participating GPU miners. Dynex stands out among the best DeSci projects for its effectiveness in quantum computing and its restricted availability.

The total supply of the token is 110 million. At the time of writing, there are 87,177,020 DNX in circulation. Mine all of the coins will take around four years according to the specified emission timetable, which follows a smooth emission curve. It is worth noting that  ICOs, pre-mine, or pre-allocation programs were provided to investors.

The community will use a vote procedure to decide whether or not to approve project proposals that holders of AXGT can submit to AxonDAO for possible financing from the DAO’s research fund. You make a direct contribution to scientific research as an AXGT holder. Purchasing or selling, every AXGT transaction contributes to funding future initiatives supported by the AxonDAO community.  Cutting out intermediaries and established financial institutions, a part of transaction fees—1%—go directly toward funding our research fund.

Using AxH AxonDAO’s App, you can transform your intellectual property (IP) into AXGT tokens. Afterward, AXGT may be changed into $ETH, $BTC, and $USDT. Revenues, earnings from the DeSci projects of AxonDAO LLC, BTC, data assets, IP NFTs, Bitcoin, other DAO tokens, other tokens and digital currencies, and maybe physical assets like metals will be the foundation for AXGT. The total and max supply is 1,000,000,000, and the coin enjoys a $53,057,931 market cap.

Tokenization of all DAO assets and DeSci projects on the platform will occur internally or by outside parties so that $HAIR token holders can always examine the assets that the DAO is in charge of. At launch, the Treasury solely had the $HAIR ERC20 token, a fully on-chain asset as it doesn’t refer to any off-chain documents or entities. A total of one billion $HAIR tokens have been created.

The coin’s market cap is $27,856,482, and its Fully Diluted Valuation supply is $66,631,733. The total supply is 1,533,338, and the maximum supply is unlimited.

The blockchain’s hospital utility coin, $GALEON, will be suggested and made available to hospitals at the appropriate moment. $GALEON has already undergone a methodical “buy-back and burn.” By locking your $GALEON for a predetermined amount of time, three years, you may stake your way to earning money from DeSci projects. Several token-limited staking schemes are available on Galeon’s dashboard. Programs for Masters, Fans, and Knights are already complete. Staking in the King, Jarl, and Karl programs is still possible. 

The coin works on the BSC and ETH blockchains. The total supply is 1,281,408,370, while the maximum can be 4B Galeons. The circulating supply is 1,281,408,370 $GALEON.