Top Crypto/ Web3 Venture Capital Firms Investing in 2025

Sequoia is a long‑standing venture firm that has built a reputation for backing founders very early, helping them scale, and often staying alongside them well into growth. It stands out for its ability to spot foundational tech early (including in blockchain and crypto infrastructure).

It’s also leaving a global footprint with its willingness to provide not just money but network, mentorship, and follow‑on support. In the Web3 space, it has deployed funds, joined token projects, and backed infrastructure protocols. If you’re a project or investor looking to understand major flows of capital, Sequoia is a key lens.

Pantera Capital is a leading player among the top crypto venture capital firms, poised among the very first institutional-backed asset managers to go all-in on blockchain and digital assets.

Founded in 2003 and shifted into crypto investing in 2013, it’s now managing over $4 billion.

It also supports a wide range of companies from early blockchain infrastructure to token-first protocols. Due to its early timing, broad strategy, and proven track record, it gives you insight into where money is flowing in Web3 and who gets the deals.

Polychain Capital is one of the most popular names among top crypto VC firms.  It was started by Olaf Carlson-Wee, one of the early employees at Coinbase. The firm focuses on funding early blockchain projects that build real infrastructure for Web3, not just tokens or short-term trends.

What makes Polychain stand out is its research-based approach and strong belief in long-term innovation. It invests in projects shaping how decentralized systems work, including networks like Tezos, Uniswap, and Coinbase.

Digital Currency Group (DCG) is one of the most active crypto venture investment firms that invests in blockchain and Web3 startups around the world. It was founded by Barry Silbert and has become known for backing some of the biggest names in crypto. Beyond investing, DCG actually runs major players like Grayscale, and Foundry, giving it a unique edge in the Web3 ecosystem.

Recently, DCG has been expanding its reach by funding more startups in Africa and other emerging markets.

Blockchain Capital is a venture capital firm that only invests in crypto and blockchain projects. They are one of the first firms to focus fully on Web3, managing over $2 billion in assets.

In September 2023, they raised $580 million for two new funds to invest in more Web3 projects. They work with both traditional equity and crypto token deals, giving you different ways to get funding.

Union Square Ventures, or USV, is a venture capital firm based in New York that has been investing in Web3 and crypto projects for several years. They focus on backing networks and platforms that can grow big and change the way people use technology.

The firm stands out in its approach to look for companies that are creating new ways of doing things in large markets. USV has supported well-known crypto projects like Uniswap, Polygon, and Arweave.

Multicoin Capital is a crypto investment firm that started in 2017 and focuses on picking specific sectors, like DeFi, payments, real-world assets, and ZK cryptography. The firm goes beyond investing by getting involved with the projects and helping them grow. They manage both a master fund and a venture fund. In addition, their current investments come from their third venture fund, a $422 million pool raised in January 2022.

The firm had highlighted that 2025 will be a big year for tokenized securities and AI-powered Web3 models, and they added Brian Strugats as their new Head Trader.

Founders Fund is a big venture capital firm co-founded by Peter Thiel and a few others. They are known for backing bold ideas that aim to solve big problems, not just small improvements. While they don’t focus only on crypto, they have been investing more in Web3 projects recently, including a stake in the crypto accelerator Alliance in 2024.

If you’re building, investing, or watching the space, Founders Fund shows that serious, top-tier VCs are looking at blockchain and Web3 as a space with real potential.

YZi Labs, which used to be called Binance Labs, is the investment arm of the Binance ecosystem. They focus on supporting Web3 startups and founders by giving money, guidance, and access to a big network of projects and users. The firm supports through programs that help projects grow, connections to a big network of users, and guidance from top leaders like Changpeng Zhao (CZ) and Ella Zhang.

They started their Web3 operations around 2017 and  rebranded to YZi Labs  in January 2025, as they expanded into areas like AI and biotech. Later, in October 2025, they launched a US$1 billion Builder Fund to back new projects on the BNB Chain.

Circle Ventures is the investment arm of Circle, the company behind the USDC stablecoin. They stand out by letting you use Circle’s payment and stablecoin tools and connect you to a network of other founders and investors. They started focusing on Web3 projects around 2022‑2023 as Circle expanded into blockchain and tokenized assets.

Recently, they backed a $20 million African Blockchain Fund to support new Web3 projects in Africa, showing they are actively investing in the growing global market.

These top Web3 venture capital firms show that smart money is moving where real infrastructure, scalable networks, and practical blockchain solutions are being built. The next phase of Web3 growth will focus on projects that combine technology with real-world use cases, like payments, DeFi, and tokenized assets. Understanding how these firms operate, what trends they back, and which sectors are gaining attention can give you a clearer picture of where opportunities and innovation are headed.